Nifedipine use was associated with a 7.4-mm Hg reduction (-14.4 to -0.4 mm Hg) in central aortic pressure, measured by pulse wave analysis. Mean blood pressure was 134/84 mm Hg with labetalol and 134/85 mm Hg with nifedipine (mean difference systolic: 0.3 mm Hg, and diastolic: -1.9 mm Hg ). Maximum blood pressure after randomization was 161/101 mm Hg with labetalol versus 163/105 mm Hg with nifedipine (mean difference systolic: 1.2 mm Hg, diastolic: 3.3 mm Hg ). Analysis included 112 women (98%) who completed the study (labetalol n=55, nifedipine n=57). Open-label first-line antihypertensive treatment was randomly assigned: labetalol- (200-1800 mg/d) or nifedipine-modified release (20-80 mg/d). Pregnant women with chronic hypertension (12 +0 -27 +6 weeks' gestation) were enrolled at 4 UK centers (August 2014 to October 2015). Webster, Louise M Myers, Jenny E Nelson-Piercy, Catherine Harding, Kate Cruickshank, J Kennedy Watt-Coote, Ingrid Khalil, Asma Wiesender, Cornelia Seed, Paul T Chappell, Lucy Cĭata from randomized controlled trials to guide antihypertensive agent choice for chronic hypertension in pregnancy are limited this study aimed to compare labetalol and nifedipine, additionally assessing the impact of ethnicity on treatment efficacy. Labetalol Versus Nifedipine as Antihypertensive Treatment for Chronic Hypertension in Pregnancy: A Randomized Controlled Trial. On withdrawal of nifedipine, symptomatic pulmonary hypertension recurred within 48 hours and was controlled by reintroduction of low-dose nifedipine. In a young woman with primary pulmonary hypertension, treatment with low-dose nifedipine resulted in resolution of symptoms and of tricuspid regurgitation. Rapid recurrence of pulmonary hypertension following cessation of nifedipine.

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